Here we go.
A 鼓舞型:比如你的车子发动不起来了,鼓捣许久后,成功,"Here we go!"
B 泄气型:比如你刚刚坐过山车坐得头晕眼花,你朋友一定要你陪他再坐一次,你可以叹道:"Here we go again..."
如果在1.中是你朋友帮你发动的车,他可以说 "There you go!"
直译当然是"(让我们)走吧,出发,开始(干)",
但在具体句子里要看上下文.
Here we go! Warm up your body first.
He is drunk. Here we go. He has a lot to talk about